A family member of the victim called police to the home in the 7400 block of Crestmont Road at approximately 11:20 a.m., police said.
The name of the woman has not been released pending notification of family members.
The woman was stabbed multiple times to the body and died on the scene, police said.
Anyone with information is asked to call Crimestoppers at 822-1111 or toll-free 1-877-903-STOP(7867).
You could receive a cash reward of up to $2,500 for information leading to the arrest and indictment of the person responsible.