1. San Francisco (Nov. 25, 3:15 p.m.)
Was there any doubt that this would be the most-intriguing game of the season? So many reasons. The 49ers knocked the Saints out of the playoffs this past season in the best game of the postseason. Call it the Gregg Williams Derby ; the audio released by Sean Pamphilon pretty much nailed this one to the No. 1 spot. There’s little love lost between these two programs right now. We expect the Superdome to be absolutely out of control for this one.